Kanouté's first games for Sevilla against Tottenham Hotspur led to his scoring a (somewhat controversial) penalty at the Estadio Ramón Sánchez Pizjuán in a game marred by crowd trouble, and an excellent goal at White Hart Lane, leaving the final aggregate score 4–3 to Sevilla .
The 2006–07 season has proved his most productive and has earned him much praise for the prominent role he has played in leading Sevilla's surprising charge on three fronts. Challenging for the Copa del Rey 2006–07, where they played Getafe in the final, as well as the UEFA Cup and La Liga. The previous year's UEFA Cup had featured just a cameo appearance for him in a comfortable victory, although he grabbed a late goal. Nonetheless, he secured his first honour of the season on 16 May with Sevilla's victory over Espanyol on penalties, after a 2–2 draw after extra time. Kanouté had seemingly retained the title for Sevilla with his extra-time goal (his fourth of the tournament) to make it 2–1, but a late equalizer prompted penalties. Kanouté scored the first in a 3–1 penalty triumph.
Sevilla's title challenge that year ultimately unravelled and Real Madrid took the title, with Kanouté's side in third Since then, Kanouté has been a consistent—if not explosive—member of the club, helping Sevilla qualify for a UEFA Cup position in 2008 and a Champions League direct qualification in 2009.
On the first day of the 2009–10 campaign, Kanouté got two yellow cards for bad fouls against Valencia and was sent off in first half stoppage time. Klik here: 12BET!